Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment, Chinese Medicine
Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro. Recently, much attention has been paid to the therapeutic role of artemisinin in liver diseases. Several studies suggest that artemisinin and its derivatives can protect the liver through different mechanisms, such as those pertaining to inflammation, proliferation, invasion, metastasis, and induction of apoptosis and autophagy. In this review, we provide a comprehensive discussion of the underlying molecular mechanisms and signaling pathways of artemisinin and its derivatives in treating liver diseases. Further pharmacological research will aid in determining whether artemisinin and its derivatives may serve as promising medicines for the treatment of liver diseases in the future.
Malaria Nature Reviews Disease Primers
Artemisinin derivatives available as co-formulations
Enhancing the antimalarial activity of artesunate
Artemisinin anti-malarial drugs in China - ScienceDirect
Molecular insights into artemisinin resistance in Plasmodium falciparum: An updated review - ScienceDirect
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Schematic of artemisinin derivatives affecting immune and inflammation.
Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment, Chinese Medicine
Frontiers The Ototoxicity of Antimalarial Drugs—A State of the Art Review
Artemisinin therapy for malaria - Lasker Foundation
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PDF] Artemisinins: pharmacological actions beyond anti-malarial.
Pharmacology of Antimalarial Drugs, Current Anti-malarials
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Chemical structure of compounds derived from traditional Chinese
