Cureus, Choices and Challenges With Drug Therapy in Postural Orthostatic Tachycardia Syndrome: A Systematic Review
The literature on pharmacologic treatments for postural orthostatic tachycardia syndrome (POTS) is inconsistent and unstandardized. Therefore, we aimed to evaluate choices in pharmacologic treatment options for POTS and the challenges encountered in the studies. We searched numerous databases like PubMed, Scopus, Embase, Web of Science, and Google Scholar for literature published before April 8, 2023. The search was done to retrieve potential peer-reviewed articles that explored drug therapy in POTS. Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were used to conduct the systematic review. Of the 421 potential articles assessed, 17 met the inclusion criteria. Results demonstrated that pharmacologic treatment options for POTS were effective in reducing symptoms of POTS, but most of the studies were underpowered. Several were terminated due to various reasons. Midodrine ivabradine, bisoprolol, fludrocortisone, droxidopa, desmopressin, propranolol, modafinil, methylphenidate, and melatonin have been studied with positive impact but sample sizes that were low in the range of 10-50 subjects. Therefore, we concluded the treatment options effectively improve symptoms of POTS and increase orthostatic tolerance, but more evidence is needed as most studies had a low sample size and thus are underpowered.
Perspective Chapter: Cardiovascular Post-Acute COVID-19 Syndrome – Definition, Clinical Scenarios, Diagnosis, and Management
POTS Syndrome: Ultimate Patient Guide by Cardiologist • MyHeart
Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection
Ivabradine in children with postural orthostatic tachycardia syndrome: a retrospective study, Cardiology in the Young
JPM, Free Full-Text
Frontiers Cardiovascular and autonomic dysfunction in long-COVID syndrome and the potential role of non-invasive therapeutic strategies on cardiovascular outcomes
Distinct Hemodynamic Responses That Culminate With Postural Orthostatic Tachycardia Syndrome - ScienceDirect
Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 - Autonomic Neuroscience: Basic and Clinical
Distinct Hemodynamic Responses That Culminate With Postural Orthostatic Tachycardia Syndrome - ScienceDirect
POTS Syndrome: Ultimate Patient Guide by Cardiologist • MyHeart
PDF) Role of NASA 10-minute Lean Test in diagnosing postural orthostatic tachycardia syndrome: a preliminary study in young population
PDF] Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Cureus, Benefits and Risks of Medications Used in the Management of Hypotension: A Review
Cureus, Alpha-2 Agonists in Children and Adolescents With Post-traumatic Stress Disorder: A Systematic Review
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm
