Comment on: Proposal for a new diagnostic classification of
Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap (SJS/TEN), collectively referred to SJS/TEN, form a spectrum of severe life-threatening adverse drug reactions whose pathomechanism is not fully understood. The article "Photodistributed Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Proposal for a New Diagnostic Classification" by McKinley et. al., discusses a distinct distribution of epidermal necrosis in SJS/TEN, attributable to preceding exposure to ultraviolet radiation (UVR), and relative sparing of photo-protected areas. After reviewing numerous cases within the Immune-mediated Adverse drug Reactions in African HIV endemic setting Register and Biorepository (IMARI-SA) at the University of Cape Town with a similar clinical pattern as those published by McKinley et. al., we propose that the relative sparing of some areas giving an impression of photo-distribution is due to localised increase in skin pressure that reduces the blood supply in that area below a critical threshold. A dip in blood supply below this critical threshold quantitively limited T lymphocytes and cytokines that drive SJS/TEN to reach and damage the skin.
Nicole Michels's research works Rocky Vista University, Parker and other places
Heat map showing similarity of PFAS concentration-profiles in 47 unique
Biobank sample workflow. Residual samples are biospecimens that are
119923 PDFs Review articles in NECROSIS
100179 PDFs Review articles in ULTRAVIOLET RAYS
Rannakoe LEHLOENYA, Professor (Associate), FCDerm(SA), University of Cape Town, Cape Town, UCT, Department of Medicine, Division of Dermatology
Advanced field laboratory setup used for Ebola virus disease outbreak
Study Selection Process to Identify Cases of Photodistributed
Biobank sample workflow. Residual samples are biospecimens that are
Procedures for Remnant Biospecimen Investigation in Sepsis (REMISE)
PDF) Comment on: Proposal for a new diagnostic classification of photodistributed Stevens–Johnson syndrome and toxic epidermal necrolysis
