Figure 1, The steps of regenerative medicine. - StemBook - NCBI
The production of cellular therapies requires the optimization of four steps: first, isolating and culturing cells that can be readily obtained from a patient in a non-invasive fashion. Second, the reprogramming of these cells into a pluripotent state. Third, the directed differentiation of those patient-specific pluripotent cells into the cell type relevant to their disease. And, fourth, techniques for repairing any intrinsic disease-causing genetic defects and transplantation of the repaired, differentiated cells into the patient. Notably, these disease-relevant patient cells can also be used for in vitro disease modeling which may yield new insights into disease mechanisms and drug discovery.
IJMS, Free Full-Text
Cells, Free Full-Text
Lancet Commission: Stem cells and regenerative medicine - The Lancet
The neural stem cell microenvironment - StemBook - NCBI Bookshelf
Basic pluripotent stem cell culture protocols - StemBook - NCBI
Figure 1, Retention versus stress-induced mobilization of HSPCs
Differential role of natural killer group 2D in recognition and
Basic pluripotent stem cell culture protocols - StemBook - NCBI
Figure 1, [Alternative routes for manufacturing, distribution
Application of Stem Cell Technology in Dental Regenerative
