The molecular interactions between hosts, vectors and pathogens drive the etiology of infectious diseases. At first sight, the Guillain-Barré and Alpha-Gal syndromes have quite different etiologies but, as proposed here, a closer look into the immune response to galactose-containing oligosaccharide structures that characterizes these two diseases reveals striking commonalities. In this Opinion paper, we address the main molecular drivers of two apparently unrelated diseases, and how the characterization of the immune response and immunological tolerance would advance the control and prevention of these diseases.
Iván PACHECO, PhD Student, University of Castilla-La Mancha, Ciudad Real, Sanidad y Biotecnología (SaBio)
La polarización de las células dendríticas (DC) determina la
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Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome
Guillain–Barré syndrome in Asia Journal of Neurology, Neurosurgery & Psychiatry
Emergence and significance of carbohydrate-specific antibodies
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Jose DE LA FUENTE, Professor (Full), PhD, University of Castilla-La Mancha, Ciudad Real, Sanidad y Biotecnología (SaBio)
Immunoglobulin and Monoclonal Antibody Therapies in Guillain-Barré Syndrome
Frontiers Intensive Care and Treatment of Severe Guillain–Barré Syndrome
Frontiers Biosynthesis of α-Gal Epitopes (Galα1-3Galβ1-4GlcNAc-R) and Their Unique Potential in Future α-Gal Therapies