Background Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology. Methods We conducted a nested case-control study within the Syncope Study of Unselected Population in Malmö (SYSTEMA) cohort including 396 patients (age range, 15–50 years) with either POTS (n = 113) or normal hemodynamic response during passive head-up-tilt test (n = 283). We used a targeted approach to explore changes in cardiovascular proteomics associated with POTS through a sequential two-stage process including supervised principal component analysis and univariate ANOVA with Bonferroni correction. Results POTS patients were younger (26 vs. 31 years; p < 0.001) and had lower BMI than controls. The discovery algorithm identified growth hormone (GH) and myoglobin (MB) as the most specific biomarker fingerprint for POTS. Plasma level of GH was higher (9.37 vs 8.37 of normalised protein expression units (NPX); p = 0.002), whereas MB was lower (4.86 vs 5.14 NPX; p = 0.002) in POTS compared with controls. In multivariate regression analysis, adjusted for age and BMI, and stratified by sex, lower MB level in men and higher GH level in women remained independently associated with POTS. Conclusions Cardiovascular proteomics analysis revealed sex-specific biomarker signature in POTS featured by higher plasma level of GH in women and lower plasma level of MB in men. These findings point to sex-specific immune-neuroendocrine dysregulation and deconditioning as potentially key pathophysiological traits underlying POTS.
Dr. Artur Fedorowski Publications
Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies - ScienceDirect
Plasma proteomic profiling in postural orthostatic tachycardia syndrome ( POTS) reveals new disease pathways
Frontiers ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data
COVID Prolongado, PDF, Myocardial Infarction
Small molecule metabolites: discovery of biomarkers and therapeutic targets. - Abstract - Europe PMC
PDF) Challenges of Introducing New Biomarker Products for Neuropsychiatric Disorders into the Market
iBright Imaging System Resources
Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID
Frontiers ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature