Pathophysiology of Crohn's disease inflammation and recurrence

Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influenced by a complex pathogenesis in which inflammation plays a key role. Crohn’s disease evolution is mediated by a complex alteration of the inflammatory response which is characterized by alterations of the innate immunity of the intestinal mucosa barrier together with a remodeling of the extracellular matrix through the expression of metalloproteins and increased adhesion molecules expression, such as MAcCAM-1. This reshaped microenvironment enhances leucocytes migration in the sites of inflammation, promoting a TH1 response, through the production of cytokines such as IL-12 and TNF-α. IL-12 itself and IL-23 have been targeted for the medical treatment of CD. Giving the limited success of medical therapies, the treatment of the disease is invariably surgical. This review will highlight the role of inflammation in CD and describe the surgical approaches for the prevention of the almost inevitable recurrence.

Nanomaterials, Free Full-Text

Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling - ScienceDirect

Frontiers Comparative diet-gut microbiome analysis in Crohn's disease and Hidradenitis suppurativa

Updated review on immune factors in pathogenesis of Crohn's disease

Cells, Free Full-Text

Frontiers Diagnostic and Predictive Value of Immune-Related Genes in Crohn's Disease

Crohn's disease - Herbal Reality

Overview and Risk Factors for Crohn's Disease - Irish Pharmacy News

Frontiers Artificial Intelligence Enhances Studies on Inflammatory Bowel Disease

Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling